The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may...

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Main Authors: Yanjun Tian, Ruijiao Chen, Yunlu Jiang, Bo Bai, Tongju Yang, Haiqing Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Neurology
Subjects:
apelin/APJ system
ischemic stroke
signaling pathways
neuroprotection
molecular mechanisms
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00075/full
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spelling doaj-e0e469cfb60444069b2f9a78fe5cffe42020-11-25T00:34:56ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-03-011110.3389/fneur.2020.00075500907The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic TargetYanjun Tian0Ruijiao Chen1Yunlu Jiang2Yunlu Jiang3Bo Bai4Tongju Yang5Haiqing Liu6Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, ChinaCollaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, ChinaSchool of Mental Health, Jining Medical University, Jining, ChinaInstitute of Neurobiology, Jining Medical University, Jining, ChinaInstitute of Neurobiology, Jining Medical University, Jining, ChinaDepartment of Pharmacy, People's Hospital of Zoucheng City, Jining, ChinaDepartment of Physiology, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian, ChinaThe orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic stroke. An in-depth knowledge of the pathophysiological effects of the apelin/APJ system and the underlying mechanisms will help to develop novel therapeutic interventions for ischemic stroke.https://www.frontiersin.org/article/10.3389/fneur.2020.00075/fullapelin/APJ systemischemic strokesignaling pathwaysneuroprotectionmolecular mechanisms
collection DOAJ
language English
format Article
sources DOAJ
author Yanjun Tian
Ruijiao Chen
Yunlu Jiang
Yunlu Jiang
Bo Bai
Tongju Yang
Haiqing Liu
spellingShingle Yanjun Tian
Ruijiao Chen
Yunlu Jiang
Yunlu Jiang
Bo Bai
Tongju Yang
Haiqing Liu
The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
Frontiers in Neurology
apelin/APJ system
ischemic stroke
signaling pathways
neuroprotection
molecular mechanisms
author_facet Yanjun Tian
Ruijiao Chen
Yunlu Jiang
Yunlu Jiang
Bo Bai
Tongju Yang
Haiqing Liu
author_sort Yanjun Tian
title The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_short The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_full The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_fullStr The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_full_unstemmed The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
title_sort protective effects and mechanisms of apelin/apj system on ischemic stroke: a promising therapeutic target
publisher Frontiers Media S.A.
series Frontiers in Neurology
issn 1664-2295
publishDate 2020-03-01
description The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic stroke. An in-depth knowledge of the pathophysiological effects of the apelin/APJ system and the underlying mechanisms will help to develop novel therapeutic interventions for ischemic stroke.
topic apelin/APJ system
ischemic stroke
signaling pathways
neuroprotection
molecular mechanisms
url https://www.frontiersin.org/article/10.3389/fneur.2020.00075/full
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