Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extract

Objectives: This study aimed to investigate the presence of oxidative stress and inflammation in ischaemic stroke patients by measuring malondialdehyde (MDA), total antioxidant status (TAS), and highly-sensitivity C-reactive protein (hsCRP) in the early post-ischaemic period, and to determine the ro...

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Main Authors: Imad A-J Thanoon, Hilmy AS Abdul-Jabbar, Dhia A Taha
Format: Article
Language:English
Published: Sultan Qaboos University 2012-05-01
Series:Sultan Qaboos University Medical Journal
Subjects:
Online Access:https://journals.squ.edu.om/index.php/squmj/article/view/1674
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spelling doaj-e0df805df9a74485afa9d78f6052a95a2020-11-25T03:24:55ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal 2075-051X2075-05282012-05-011221972051599Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extractImad A-J Thanoon0Hilmy AS Abdul-Jabbar1Dhia A Taha2College of Medicine, University of Mosul, Mosul, IraqNeurosurgery Unit, Iben Seena Hospital, Mosul, IraqSharkat General Hospital, Salah Al-Din Health Institute, Salah Al-Din, IraqObjectives: This study aimed to investigate the presence of oxidative stress and inflammation in ischaemic stroke patients by measuring malondialdehyde (MDA), total antioxidant status (TAS), and highly-sensitivity C-reactive protein (hsCRP) in the early post-ischaemic period, and to determine the role of Ginkgo biloba therapy in correcting the markers of oxidative stress and inflammation. Methods: This study was conducted at Ibn Seena Hospital, Mosul City, Iraq and included 31 cerebrovascular accident (CVA) patients and 30 healthy controls. Ischaemic stroke patients were divided into two groups: group I (n = 15) received conventional therapy; group II (n = 16) received conventional therapy with G. biloba (1500 mg/day) for 30 days. Blood samples were obtained from patients and controls before treatment and assays done of serum levels of MDA, TAS, and hsCRP. For CVA patients, a post-treatment blood sample was taken and the same parameters reassessed. Results: Compared with the controls, patients’ serum levels of MDA, and hsCRP were significantly higher (P ≤0.001) and TAS significantly lower. Group I and II patients reported a significant reduction in serum levels of MDA and hsCRP and a significant increase in serum levels of TAS, in comparison with pre-treatment levels. There was no significant difference (P = 0.19) in serum MDA levels between groups I and II, whereas, serum TAS levels were significantly higher (P ≤0.01) and hsCRP significantly lower (P ≤0.01) in group II. Conclusion: Acute stroke is associated with oxidative stress and inflammatory response in the early period. G. biloba plays a potential role in reducing oxidative damage and inflammatory response.https://journals.squ.edu.om/index.php/squmj/article/view/1674cerebrovascular accidentc-reactive proteinginkgo bilobaischaemiastrokemalondialdehydeoxidative stressantioxidantiraq.
collection DOAJ
language English
format Article
sources DOAJ
author Imad A-J Thanoon
Hilmy AS Abdul-Jabbar
Dhia A Taha
spellingShingle Imad A-J Thanoon
Hilmy AS Abdul-Jabbar
Dhia A Taha
Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extract
Sultan Qaboos University Medical Journal
cerebrovascular accident
c-reactive protein
ginkgo biloba
ischaemia
stroke
malondialdehyde
oxidative stress
antioxidant
iraq.
author_facet Imad A-J Thanoon
Hilmy AS Abdul-Jabbar
Dhia A Taha
author_sort Imad A-J Thanoon
title Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extract
title_short Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extract
title_full Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extract
title_fullStr Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extract
title_full_unstemmed Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) : The role of Ginkgo biloba extract
title_sort oxidative stress and c-reactive protein in patients with cerebrovascular accident (ischaemic stroke) : the role of ginkgo biloba extract
publisher Sultan Qaboos University
series Sultan Qaboos University Medical Journal
issn 2075-051X
2075-0528
publishDate 2012-05-01
description Objectives: This study aimed to investigate the presence of oxidative stress and inflammation in ischaemic stroke patients by measuring malondialdehyde (MDA), total antioxidant status (TAS), and highly-sensitivity C-reactive protein (hsCRP) in the early post-ischaemic period, and to determine the role of Ginkgo biloba therapy in correcting the markers of oxidative stress and inflammation. Methods: This study was conducted at Ibn Seena Hospital, Mosul City, Iraq and included 31 cerebrovascular accident (CVA) patients and 30 healthy controls. Ischaemic stroke patients were divided into two groups: group I (n = 15) received conventional therapy; group II (n = 16) received conventional therapy with G. biloba (1500 mg/day) for 30 days. Blood samples were obtained from patients and controls before treatment and assays done of serum levels of MDA, TAS, and hsCRP. For CVA patients, a post-treatment blood sample was taken and the same parameters reassessed. Results: Compared with the controls, patients’ serum levels of MDA, and hsCRP were significantly higher (P ≤0.001) and TAS significantly lower. Group I and II patients reported a significant reduction in serum levels of MDA and hsCRP and a significant increase in serum levels of TAS, in comparison with pre-treatment levels. There was no significant difference (P = 0.19) in serum MDA levels between groups I and II, whereas, serum TAS levels were significantly higher (P ≤0.01) and hsCRP significantly lower (P ≤0.01) in group II. Conclusion: Acute stroke is associated with oxidative stress and inflammatory response in the early period. G. biloba plays a potential role in reducing oxidative damage and inflammatory response.
topic cerebrovascular accident
c-reactive protein
ginkgo biloba
ischaemia
stroke
malondialdehyde
oxidative stress
antioxidant
iraq.
url https://journals.squ.edu.om/index.php/squmj/article/view/1674
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AT dhiaataha oxidativestressandcreactiveproteininpatientswithcerebrovascularaccidentischaemicstroketheroleofginkgobilobaextract
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