Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus

Mounting evidence has demonstrated that Bit1 has been investigated as an etiological factor for certain cancers, including esophageal squamous cell carcinoma reported in our previous study, but data regarding possible roles of Bit1 in esophageal squamous cell carcinoma and esophageal adenocarcinoma...

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Main Authors: Jing Chen, Hongtao Liu, Pan Gao, Yiran Hui, Zhenzhen Yang, Xiaqing Zhang, Peirong Xu, Fang Tian, Tianli Fan
Format: Article
Language:English
Published: IOS Press 2017-05-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317708267
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spelling doaj-e0dc30c8e5514475a45577e793f811082021-05-02T19:05:24ZengIOS PressTumor Biology1423-03802017-05-013910.1177/1010428317708267Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagusJing Chen0Hongtao Liu1Pan Gao2Yiran Hui3Zhenzhen Yang4Xiaqing Zhang5Peirong Xu6Fang Tian7Tianli Fan8Department of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaLaboratory for Cell Biology, School of Life Science, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaLaboratory for Cell Biology, School of Life Science, Zhengzhou University, Zhengzhou, ChinaSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathophysiology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaMounting evidence has demonstrated that Bit1 has been investigated as an etiological factor for certain cancers, including esophageal squamous cell carcinoma reported in our previous study, but data regarding possible roles of Bit1 in esophageal squamous cell carcinoma and esophageal adenocarcinoma remain to be elucidated. The purpose of this study was to examine whether Bit1 can be a novel diagnostic marker for the patients with esophageal squamous cell carcinoma and esophageal adenocarcinoma. The results revealed that Bit1 level in esophageal squamous cell carcinoma was significantly higher than that in esophageal adenocarcinoma tissues ( p < 0.05); notably, Bit1 level in esophageal adenocarcinoma tissues was lower than that in paired normal tissues but no difference was found ( p > 0.05). Bit1 expression patterns were completely in accordance with matrix metalloproteinase 2 and Bcl-2 in esophageal squamous cell carcinoma and esophageal adenocarcinoma. In addition, Bit1, Bcl-2, and matrix metalloproteinase 2 expression patterns in different differentiated esophageal squamous cell carcinoma were higher than those in corresponding normal esophageal tissues. Bit1 expression in poorly differentiated esophageal squamous cell carcinoma was significantly higher than that in normal esophageal tissues ( p < 0.05) but not in moderately and well-differentiated esophageal squamous cell carcinoma. Matrix metalloproteinase 2 expression patterns in poorly and moderately differentiated esophageal squamous cell carcinoma were significantly higher than those in corresponding normal esophageal tissues ( p < 0.01) but not in well-differentiated esophageal squamous cell carcinoma tissue ( p > 0.05). Bcl-2 expression patterns in various differentiated esophageal squamous cell carcinoma were higher than those in corresponding normal esophageal tissues with no statistical differences ( p > 0.05). Importantly, Bit1 expression was positively correlated with both matrix metalloproteinase 2 and Bcl-2 expression in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues ( p < 0.05). Collectively, these preliminary data support further investigation of Bit1 as an important diagnostic factor for esophageal squamous cell carcinoma and esophageal adenocarcinoma.https://doi.org/10.1177/1010428317708267
collection DOAJ
language English
format Article
sources DOAJ
author Jing Chen
Hongtao Liu
Pan Gao
Yiran Hui
Zhenzhen Yang
Xiaqing Zhang
Peirong Xu
Fang Tian
Tianli Fan
spellingShingle Jing Chen
Hongtao Liu
Pan Gao
Yiran Hui
Zhenzhen Yang
Xiaqing Zhang
Peirong Xu
Fang Tian
Tianli Fan
Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus
Tumor Biology
author_facet Jing Chen
Hongtao Liu
Pan Gao
Yiran Hui
Zhenzhen Yang
Xiaqing Zhang
Peirong Xu
Fang Tian
Tianli Fan
author_sort Jing Chen
title Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus
title_short Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus
title_full Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus
title_fullStr Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus
title_full_unstemmed Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus
title_sort preliminary evaluation for bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus
publisher IOS Press
series Tumor Biology
issn 1423-0380
publishDate 2017-05-01
description Mounting evidence has demonstrated that Bit1 has been investigated as an etiological factor for certain cancers, including esophageal squamous cell carcinoma reported in our previous study, but data regarding possible roles of Bit1 in esophageal squamous cell carcinoma and esophageal adenocarcinoma remain to be elucidated. The purpose of this study was to examine whether Bit1 can be a novel diagnostic marker for the patients with esophageal squamous cell carcinoma and esophageal adenocarcinoma. The results revealed that Bit1 level in esophageal squamous cell carcinoma was significantly higher than that in esophageal adenocarcinoma tissues ( p < 0.05); notably, Bit1 level in esophageal adenocarcinoma tissues was lower than that in paired normal tissues but no difference was found ( p > 0.05). Bit1 expression patterns were completely in accordance with matrix metalloproteinase 2 and Bcl-2 in esophageal squamous cell carcinoma and esophageal adenocarcinoma. In addition, Bit1, Bcl-2, and matrix metalloproteinase 2 expression patterns in different differentiated esophageal squamous cell carcinoma were higher than those in corresponding normal esophageal tissues. Bit1 expression in poorly differentiated esophageal squamous cell carcinoma was significantly higher than that in normal esophageal tissues ( p < 0.05) but not in moderately and well-differentiated esophageal squamous cell carcinoma. Matrix metalloproteinase 2 expression patterns in poorly and moderately differentiated esophageal squamous cell carcinoma were significantly higher than those in corresponding normal esophageal tissues ( p < 0.01) but not in well-differentiated esophageal squamous cell carcinoma tissue ( p > 0.05). Bcl-2 expression patterns in various differentiated esophageal squamous cell carcinoma were higher than those in corresponding normal esophageal tissues with no statistical differences ( p > 0.05). Importantly, Bit1 expression was positively correlated with both matrix metalloproteinase 2 and Bcl-2 expression in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues ( p < 0.05). Collectively, these preliminary data support further investigation of Bit1 as an important diagnostic factor for esophageal squamous cell carcinoma and esophageal adenocarcinoma.
url https://doi.org/10.1177/1010428317708267
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