Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions.

Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions.

The human IgM B7-DC XAb protects mice from tumors in both therapeutic and prophylactic settings. Its mechanism of action is mediated by its binding to B7-DC/PD-L2 molecules on the surface of dendritic cells (DCs) to induce a multimolecular cap and subsequent activation of signaling cascades that det...

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Bibliographic Details
Main Authors: Suresh Radhakrishnan, Rosalyn Cabrera, Kristina M Bruns, Virginia P Van Keulen, Michael J Hansen, Sara J Felts, Larry R Pease
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2670496?pdf=render

Internet

http://europepmc.org/articles/PMC2670496?pdf=render

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