MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitment of patrolling monocytes to early atheroscleroti...

Full description

Bibliographic Details
Main Authors: Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A. Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote, Alicia G. Arroyo
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03351-4
id doaj-e0c0b515953e43daab3696ec2826dc83
record_format Article
spelling doaj-e0c0b515953e43daab3696ec2826dc832021-05-11T09:51:39ZengNature Publishing GroupNature Communications2041-17232018-03-019111610.1038/s41467-018-03351-4MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosisCristina Clemente0Cristina Rius1Laura Alonso-Herranz2Mara Martín-Alonso3Ángela Pollán4Emilio Camafeita5Fernando Martínez6Rubén A. Mota7Vanessa Núñez8Cristina Rodríguez9Motoharu Seiki10José Martínez-González11Vicente Andrés12Mercedes Ricote13Alicia G. Arroyo14Matrix Metalloproteinases in Angiogenesis and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Molecular and Genetic Cardiovascular Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Nuclear Receptor Signaling Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Matrix Metalloproteinases in Angiogenesis and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Matrix Metalloproteinases in Angiogenesis and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Proteomics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Matrix Metalloproteinases in Angiogenesis and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Nuclear Receptor Signaling Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)CIBER de Enfermedades Cardiovasculares (CIBERCV)Division of Cancer Cell Research, Institute of Medical Science, University of TokyoCIBER de Enfermedades Cardiovasculares (CIBERCV)Molecular and Genetic Cardiovascular Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Nuclear Receptor Signaling Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Matrix Metalloproteinases in Angiogenesis and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitment of patrolling monocytes to early atherosclerotic lesions, which accelerates atherosclerosis.https://doi.org/10.1038/s41467-018-03351-4
collection DOAJ
language English
format Article
sources DOAJ
author Cristina Clemente
Cristina Rius
Laura Alonso-Herranz
Mara Martín-Alonso
Ángela Pollán
Emilio Camafeita
Fernando Martínez
Rubén A. Mota
Vanessa Núñez
Cristina Rodríguez
Motoharu Seiki
José Martínez-González
Vicente Andrés
Mercedes Ricote
Alicia G. Arroyo
spellingShingle Cristina Clemente
Cristina Rius
Laura Alonso-Herranz
Mara Martín-Alonso
Ángela Pollán
Emilio Camafeita
Fernando Martínez
Rubén A. Mota
Vanessa Núñez
Cristina Rodríguez
Motoharu Seiki
José Martínez-González
Vicente Andrés
Mercedes Ricote
Alicia G. Arroyo
MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
Nature Communications
author_facet Cristina Clemente
Cristina Rius
Laura Alonso-Herranz
Mara Martín-Alonso
Ángela Pollán
Emilio Camafeita
Fernando Martínez
Rubén A. Mota
Vanessa Núñez
Cristina Rodríguez
Motoharu Seiki
José Martínez-González
Vicente Andrés
Mercedes Ricote
Alicia G. Arroyo
author_sort Cristina Clemente
title MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
title_short MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
title_full MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
title_fullStr MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
title_full_unstemmed MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
title_sort mt4-mmp deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-03-01
description Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitment of patrolling monocytes to early atherosclerotic lesions, which accelerates atherosclerosis.
url https://doi.org/10.1038/s41467-018-03351-4
work_keys_str_mv AT cristinaclemente mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT cristinarius mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT lauraalonsoherranz mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT maramartinalonso mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT angelapollan mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT emiliocamafeita mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT fernandomartinez mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT rubenamota mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT vanessanunez mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT cristinarodriguez mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT motoharuseiki mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT josemartinezgonzalez mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT vicenteandres mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT mercedesricote mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
AT aliciagarroyo mt4mmpdeficiencyincreasespatrollingmonocyterecruitmenttoearlylesionsandacceleratesatherosclerosis
_version_ 1721449108939472896

Similar Items