Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming,...

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Main Authors: Nguyen Thi Ha, Chang Hoon Lee
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
farnesyl-diphosphate farnesyltransferase 1
prognostic marker
lipid rafts
cholesterol synthesis
tumour progression
Online Access:https://www.mdpi.com/2073-4409/9/11/2352
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spelling doaj-e0bd848198214e01a13ab73debc379d22020-11-25T03:56:35ZengMDPI AGCells2073-44092020-10-0192352235210.3390/cells9112352Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour MicroenvironmentsNguyen Thi Ha0Chang Hoon Lee1College of Pharmacy, Dongguk University, Seoul 04620, KoreaCollege of Pharmacy, Dongguk University, Seoul 04620, KoreaFarnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.https://www.mdpi.com/2073-4409/9/11/2352farnesyl-diphosphate farnesyltransferase 1prognostic markerlipid raftscholesterol synthesistumour progression
collection DOAJ
language English
format Article
sources DOAJ
author Nguyen Thi Ha
Chang Hoon Lee
spellingShingle Nguyen Thi Ha
Chang Hoon Lee
Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
Cells
farnesyl-diphosphate farnesyltransferase 1
prognostic marker
lipid rafts
cholesterol synthesis
tumour progression
author_facet Nguyen Thi Ha
Chang Hoon Lee
author_sort Nguyen Thi Ha
title Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
title_short Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
title_full Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
title_fullStr Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
title_full_unstemmed Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
title_sort roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-10-01
description Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.
topic farnesyl-diphosphate farnesyltransferase 1
prognostic marker
lipid rafts
cholesterol synthesis
tumour progression
url https://www.mdpi.com/2073-4409/9/11/2352
work_keys_str_mv AT nguyenthiha rolesoffarnesyldiphosphatefarnesyltransferase1intumourandtumourmicroenvironments
AT changhoonlee rolesoffarnesyldiphosphatefarnesyltransferase1intumourandtumourmicroenvironments
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