Glucocorticoid Receptor Modulates EGFR Feedback upon Acquisition of Resistance to Monoclonal Antibodies

Glucocorticoid Receptor Modulates EGFR Feedback upon Acquisition of Resistance to Monoclonal Antibodies

Evidences of a crosstalk between Epidermal Growth Factor Receptor (EGFR) and Glucocorticoid Receptor (GR) has been reported, ranging from the modulation of receptor levels or GR mediated transcriptional repression of EGFR target genes, with modifications of epigenetic markers. The present study focu...

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Bibliographic Details
Main Authors: Valerio Gelfo, Francesca Pontis, Martina Mazzeschi, Michela Sgarzi, Maria Mazzarini, Rossella Solmi, Gabriele D’Uva, Mattia Lauriola
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Journal of Clinical Medicine
Subjects:
epidermal growth factor receptor
glucocorticoid receptor
nuclear receptor
colon cancer
resistance to monoclonal antibodies
cetuximab (CTX)
dexamethasone
mifepristone
positive feedback loops
negative feedback loops
IL-1A
IL-1B
IL-8
LRIG1
ERRFI1
DUSP1
Online Access:https://www.mdpi.com/2077-0383/8/5/600

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https://www.mdpi.com/2077-0383/8/5/600

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