Myeloid-Derived Suppressor Cells Induce Podocyte Injury Through Increasing Reactive Oxygen Species in Lupus Nephritis

Myeloid-Derived Suppressor Cells Induce Podocyte Injury Through Increasing Reactive Oxygen Species in Lupus Nephritis

The expansion of myeloid-derived suppressor cells (MDSCs) has been documented in murine models and patients with lupus nephritis (LN), but the exact role of MDSCs in this process remains largely unknown. In this study, we investigated whether MDSCs are involved in the process of podocyte injury in t...

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Bibliographic Details
Main Authors: Dongya Zhang, Jingjing Xu, Jing Ren, Liang Ding, Guoping Shi, Dan Li, Huan Dou, Yayi Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
lupus nephritis
myeloid-derived suppressor cells
podocytes
toll-like receptor-7
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01443/full

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