Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV receptor.

Bibliographic Details
Main Authors: Mayank Srivastava, Ying Zhang, Jian Chen, Devika Sirohi, Andrew Miller, Yang Zhang, Zhilu Chen, Haojie Lu, Jianqing Xu, Richard J. Kuhn, W. Andy Tao
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17638-y
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spelling doaj-e083ebec23fd4782a7cf7d04711ee3c22021-08-08T11:38:40ZengNature Publishing GroupNature Communications2041-17232020-08-0111111010.1038/s41467-020-17638-yChemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptorMayank Srivastava0Ying Zhang1Jian Chen2Devika Sirohi3Andrew Miller4Yang Zhang5Zhilu Chen6Haojie Lu7Jianqing Xu8Richard J. Kuhn9W. Andy Tao10Department of Chemistry, Purdue UniversityInstitutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan UniversityShanghai Public Health Clinical Center, Fudan UniversityDepartment of Biological Sciences, Purdue UniversityDepartment of Biological Sciences, Purdue UniversityInstitutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan UniversityInstitutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan UniversityInstitutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan UniversityInstitutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research, Fudan UniversityDepartment of Biological Sciences, Purdue UniversityDepartment of Chemistry, Purdue UniversityThe mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV receptor.https://doi.org/10.1038/s41467-020-17638-y
collection DOAJ
language English
format Article
sources DOAJ
author Mayank Srivastava
Ying Zhang
Jian Chen
Devika Sirohi
Andrew Miller
Yang Zhang
Zhilu Chen
Haojie Lu
Jianqing Xu
Richard J. Kuhn
W. Andy Tao
spellingShingle Mayank Srivastava
Ying Zhang
Jian Chen
Devika Sirohi
Andrew Miller
Yang Zhang
Zhilu Chen
Haojie Lu
Jianqing Xu
Richard J. Kuhn
W. Andy Tao
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
Nature Communications
author_facet Mayank Srivastava
Ying Zhang
Jian Chen
Devika Sirohi
Andrew Miller
Yang Zhang
Zhilu Chen
Haojie Lu
Jianqing Xu
Richard J. Kuhn
W. Andy Tao
author_sort Mayank Srivastava
title Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
title_short Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
title_full Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
title_fullStr Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
title_full_unstemmed Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
title_sort chemical proteomics tracks virus entry and uncovers ncam1 as zika virus receptor
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-08-01
description The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV receptor.
url https://doi.org/10.1038/s41467-020-17638-y
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