Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens ex vivo, suffer biological issues such as impaired DC migration capacity and laborious GMP production procedures. In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo...

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Bibliographic Details
Main Authors: Saskia Schmitt, Siret Tahk, Alina Lohner, Gerulf Hänel, Andreas Maiser, Martina Hauke, Lubna Patel, Maurine Rothe, Christine Josenhans, Heinrich Leonhardt, Marieke Griffioen, Katrin Deiser, Nadja C. Fenn, Karl-Peter Hopfner, Marion Subklewe
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
flagellin
neoantigen
vaccine
antibody
acute myeloid leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.602802/full

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