Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insu...

Full description

Bibliographic Details
Main Authors:	Anorut Jenwitheesuk, Chutikorn Nopparat, Sujira Mukda, Prapimpun Wongchitrat, Piyarat Govitrapong
Format:	Article
Language:	English
Published:	MDPI AG 2014-09-01
Series:	International Journal of Molecular Sciences
Subjects:	melatonin brain aging energy metabolism epigenetics autophagy circadian rhythm neurodegeneration sirtuins
Online Access:	http://www.mdpi.com/1422-0067/15/9/16848

id	doaj-e07e3a76cf1341ffadf170047d685bff
record_format	Article
spelling	doaj-e07e3a76cf1341ffadf170047d685bff2020-11-24T21:52:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-09-01159168481688410.3390/ijms150916848ijms150916848Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm PathwaysAnorut Jenwitheesuk0Chutikorn Nopparat1Sujira Mukda2Prapimpun Wongchitrat3Piyarat Govitrapong4Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakornpathom 73170, ThailandResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakornpathom 73170, ThailandResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakornpathom 73170, ThailandCenter for Innovation Development and Technology Transfer, Faculty of Medical Technology, Mahidol University, Salaya, Nakornpathom 73170, ThailandResearch Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakornpathom 73170, ThailandBrain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.http://www.mdpi.com/1422-0067/15/9/16848melatoninbrain agingenergy metabolismepigeneticsautophagycircadian rhythmneurodegenerationsirtuins
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anorut Jenwitheesuk Chutikorn Nopparat Sujira Mukda Prapimpun Wongchitrat Piyarat Govitrapong
spellingShingle	Anorut Jenwitheesuk Chutikorn Nopparat Sujira Mukda Prapimpun Wongchitrat Piyarat Govitrapong Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways International Journal of Molecular Sciences melatonin brain aging energy metabolism epigenetics autophagy circadian rhythm neurodegeneration sirtuins
author_facet	Anorut Jenwitheesuk Chutikorn Nopparat Sujira Mukda Prapimpun Wongchitrat Piyarat Govitrapong
author_sort	Anorut Jenwitheesuk
title	Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_short	Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_full	Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_fullStr	Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_full_unstemmed	Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_sort	melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2014-09-01
description	Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.
topic	melatonin brain aging energy metabolism epigenetics autophagy circadian rhythm neurodegeneration sirtuins
url	http://www.mdpi.com/1422-0067/15/9/16848
work_keys_str_mv	AT anorutjenwitheesuk melatoninregulatesagingandneurodegenerationthroughenergymetabolismepigeneticsautophagyandcircadianrhythmpathways AT chutikornnopparat melatoninregulatesagingandneurodegenerationthroughenergymetabolismepigeneticsautophagyandcircadianrhythmpathways AT sujiramukda melatoninregulatesagingandneurodegenerationthroughenergymetabolismepigeneticsautophagyandcircadianrhythmpathways AT prapimpunwongchitrat melatoninregulatesagingandneurodegenerationthroughenergymetabolismepigeneticsautophagyandcircadianrhythmpathways AT piyaratgovitrapong melatoninregulatesagingandneurodegenerationthroughenergymetabolismepigeneticsautophagyandcircadianrhythmpathways
_version_	1725877513808248832

Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

Similar Items