| Summary: | Objective: To study the effect of adjuvant nicorandil therapy on inflammation, plaque stability
and platelet function in patients with unstable angina. Methods: A total of 134 patients with
unstable angina who received drug therapy in our hospital between March 2015 and March
2016 were selected as the research subjects and randomly divided into the experimental
group who accepted nicorandil combined with conventional therapy and the control group
who accepted conventional therapy. 2 weeks after treatment, serum inflammation indexes
and plaque stability indexes as well as peripheral blood platelet function parameters were
determined. Results: 2 weeks after treatment, serum hs-CRP, TNF-毩, IL-18, IL-23, MMP1,
MMP2, MMP3, MMP9 and ICTP levels of experimental group were significantly lower
than those of control group; peripheral blood CD63, PAC-1, CD42b and GP-VI fluorescence
intensity as well as Angle, MA and CI levels of experimental group were significantly lower
than those of control group while R and K levels were significantly higher than those of
control group. Conclusion: Adjuvant nicorandil therapy can relieve the inflammatory response
in patients with unstable angina, and thereby inhibit the inflammation-mediated fibrous cap
degradation, plaque stability decrease, platelet activation and thrombosis.
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