Determinação de ácido valpróico em soro por cromatografia líquida de alta eficiência com detector de arranjo de diodos (CLAE-DAD), após derivatização com brometo de fenacila Determination of valproic acid in serum by high performance liquid chromatography with diode array detection (HPLC-DAD), after derivatization with phenacyl bromide

Determinação de ácido valpróico em soro por cromatografia líquida de alta eficiência com detector de arranjo de diodos (CLAE-DAD), após derivatização com brometo de fenacila Determination of valproic acid in serum by high performance liquid chromatography with diode array detection (HPLC-DAD), after derivatization with phenacyl bromide

<abstract language="eng">Valproic acid (VA) is a drug used to control seizures in several epileptic conditions. In VA pharmacotherapy, therapeutic drug monitoring is recommended to obtain adequate seizure control and avoid toxicity. The aim of this study was to validate a method for...

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Bibliographic Details
Main Authors: Marina Venzon Antunes, Viviane Nagel, Rafael Linden, Helenice Orosco Werlang, Daniela Hermes
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2009-01-01
Series:Química Nova
Subjects:
valproic acid
phenacyl bromide
HPLC-DAD
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500027

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500027

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