Digital signaling decouples activation probability and population heterogeneity

Digital signaling decouples activation probability and population heterogeneity

Digital signaling enhances robustness of cellular decisions in noisy environments, but it is unclear how digital systems transmit temporal information about a stimulus. To understand how temporal input information is encoded and decoded by the NF-κB system, we studied transcription factor dynamics a...

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Bibliographic Details
Main Authors:	Ryan A Kellogg, Chengzhe Tian, Tomasz Lipniacki, Stephen R Quake, Savaş Tay
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-10-01
Series:	eLife
Subjects:	digital signaling single-cell analysis signaling dynamics cell-to-cell heterogeneity systems biology innate immunity
Online Access:	https://elifesciences.org/articles/08931

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