Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB

Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB

Summary: The adaptor SHARPIN composes, together with the E3 ligases HOIP and HOIL1, the linear ubiquitin chain assembly complex (LUBAC). This enzymatic complex catalyzes and stamps atypical linear ubiquitin chains onto substrates to modify their fate and has been linked to the regulation of the NF-κ...

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Bibliographic Details
Main Authors: An Thys, Kilian Trillet, Sara Rosińska, Audrey Gayraud, Tiphaine Douanne, Yannic Danger, Clotilde C.N. Renaud, Luc Antigny, Régis Lavigne, Charles Pineau, Emmanuelle Com, Franck Vérité, Julie Gavard, Nicolas Bidère
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311366

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