Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

Treating Alzheimer’s disease, one of the most common neurodegenerative diseases, is of wide interest. Here, the authors report on the development of casein coated gold nanoparticles which were able to cross the blood brain barrier and protect against amyloid beta toxicity in a zebrafish model.

Bibliographic Details
Main Authors: Ibrahim Javed, Guotao Peng, Yanting Xing, Tianyu Yu, Mei Zhao, Aleksandr Kakinen, Ava Faridi, Clare L. Parish, Feng Ding, Thomas P. Davis, Pu Chun Ke, Sijie Lin
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11762-0
Description
Summary:Treating Alzheimer’s disease, one of the most common neurodegenerative diseases, is of wide interest. Here, the authors report on the development of casein coated gold nanoparticles which were able to cross the blood brain barrier and protect against amyloid beta toxicity in a zebrafish model.
ISSN:2041-1723