Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

It is thought that the chances for discovery of novel natural products increase by screening rare organisms. Here the authors analyse metabolites produced by over 2300 myxobacterial strains and, indeed, find a correlation between taxonomic distance and production of distinct secondary metabolite fam...

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Main Authors: Thomas Hoffmann, Daniel Krug, Nisa Bozkurt, Srikanth Duddela, Rolf Jansen, Ronald Garcia, Klaus Gerth, Heinrich Steinmetz, Rolf Müller
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03184-1
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spelling doaj-e04d0d9067134cffaac70fff45d6321e2021-05-11T09:46:12ZengNature Publishing GroupNature Communications2041-17232018-02-019111010.1038/s41467-018-03184-1Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteriaThomas Hoffmann0Daniel Krug1Nisa Bozkurt2Srikanth Duddela3Rolf Jansen4Ronald Garcia5Klaus Gerth6Heinrich Steinmetz7Rolf Müller8Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland UniversityHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland UniversityHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland UniversityHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland UniversityHelmholtz Centre for Infection Research (HZI), Department of Microbial DrugsHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland UniversityHelmholtz Centre for Infection Research (HZI), Department of Microbial DrugsHelmholtz Centre for Infection Research (HZI), Department of Microbial DrugsHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland UniversityIt is thought that the chances for discovery of novel natural products increase by screening rare organisms. Here the authors analyse metabolites produced by over 2300 myxobacterial strains and, indeed, find a correlation between taxonomic distance and production of distinct secondary metabolite families.https://doi.org/10.1038/s41467-018-03184-1
collection DOAJ
language English
format Article
sources DOAJ
author Thomas Hoffmann
Daniel Krug
Nisa Bozkurt
Srikanth Duddela
Rolf Jansen
Ronald Garcia
Klaus Gerth
Heinrich Steinmetz
Rolf Müller
spellingShingle Thomas Hoffmann
Daniel Krug
Nisa Bozkurt
Srikanth Duddela
Rolf Jansen
Ronald Garcia
Klaus Gerth
Heinrich Steinmetz
Rolf Müller
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
Nature Communications
author_facet Thomas Hoffmann
Daniel Krug
Nisa Bozkurt
Srikanth Duddela
Rolf Jansen
Ronald Garcia
Klaus Gerth
Heinrich Steinmetz
Rolf Müller
author_sort Thomas Hoffmann
title Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
title_short Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
title_full Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
title_fullStr Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
title_full_unstemmed Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
title_sort correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description It is thought that the chances for discovery of novel natural products increase by screening rare organisms. Here the authors analyse metabolites produced by over 2300 myxobacterial strains and, indeed, find a correlation between taxonomic distance and production of distinct secondary metabolite families.
url https://doi.org/10.1038/s41467-018-03184-1
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