High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility

Abstract Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. HPV is epitheliotropic and its replication is tightly associated with terminal keratinocyte differentiation making production and purification of high titer virus preparations for research...

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Bibliographic Details
Main Authors: Daniel J. Goetschius, Samantha R. Hartmann, Suriyasri Subramanian, Carol M. Bator, Neil D. Christensen, Susan L. Hafenstein
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83076-5