Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design.

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design.

Inhibition of the protein-protein interaction (PPI) mediated by breast-cancer-gene 1 C-terminal (BRCT) is an attractive strategy to sensitize breast and ovarian cancers to chemotherapeutic agents that induce DNA damage. Such inhibitors could also be used for studies to understand the role of this PP...

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Bibliographic Details
Main Authors: Wanli You, Yu-Ming M Huang, Smitha Kizhake, Amarnath Natarajan, Chia-En A Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4999267?pdf=render

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