The molecular pathology of thyroid neoplasms

The molecular pathology of thyroid neoplasms

<p class="Pa19"><span>The Bethesda system of reporting thyroid cytology is being currently adopted worldwide. Rapid advances have been made in the understanding of the genetics of thyroid cancers. Common genetic mutations include RAS, BRAF, p53, B Catenin, and PAX8/PPAR&gam...

Full description

Bibliographic Details
Main Author: JB Thapa
Format: Article
Language:English
Published: Association of Clinical Pathologists of Nepal 2014-04-01
Series:Journal of Pathology of Nepal
Subjects:
Thyroid
Tumours
Bethesda System
RAS
BRAF
p53
B Catenin
PAX8/PPAR?
Biological behavior
Gene therapy
Online Access:http://www.nepjol.info/index.php/JPN/article/view/10317
Description
Summary:<p class="Pa19"><span>The Bethesda system of reporting thyroid cytology is being currently adopted worldwide. Rapid advances have been made in the understanding of the genetics of thyroid cancers. Common genetic mutations include RAS, BRAF, p53, B Catenin, and PAX8/PPAR&gamma;, genes. BRAF mutations tumours are often aggressive. BRAF mutations commonly affect papillary carcinomas in the BRAF MEK ERF intracellular pathway, whereas RAS mutations commonly affect follicular carcinoma in the PL3 kinase pathway. TK inhibitors, RAS, RET, non RET, PL3, HDAC, DNMT etc. inhibitors are also being considered for therapy against these tumours. </span></p> <p class="Pa19"><span>DOI:<span>&nbsp;</span></span><span><a href="http://dx.doi.org/10.3126/jpn.v4i7.10317">http://dx.doi.org/10.3126/jpn.v4i7.10317</a> </span></p> <p><span>Journal of Pathology of Nepal (2014) Vol.<span>&nbsp;</span><strong>4</strong>, 580-583&nbsp;&nbsp;</span></p>
ISSN:2091-0797
2091-0908

Similar Items