Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates

Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates

The novel ligand HL6 was synthesized using anthranilic acid and it was undergo the chelating reaction with Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) to prepare transition metal chelates. These chelates were characterized by physicochemical methods such as elemental analysis, conductometric studies,...

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Main Authors: R. T. Vashi, C. D. Shelat, Himanshu Patel
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2010/701409
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spelling doaj-e032aac1801a470884b98213b6ac467e2020-11-24T20:58:24ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102010-01-017S1S163S16810.1155/2010/701409Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its ChelatesR. T. Vashi0C. D. Shelat1Himanshu Patel2Department of Chemistry, Navyug Science College, Surat-395009, IndiaDepartment of Chemistry, Navyug Science College, Surat-395009, IndiaDepartment of Chemistry, Navyug Science College, Surat-395009, IndiaThe novel ligand HL6 was synthesized using anthranilic acid and it was undergo the chelating reaction with Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) to prepare transition metal chelates. These chelates were characterized by physicochemical methods such as elemental analysis, conductometric studies, magnetic susceptibility, FT-IR, NMR and electronic spectra. The stoichiometry of the complexes has been found to be 1: 2 (Metal: ligand). An octahedral geometry around Co(II), Ni(II) and Mn(II), distorted octahedral geometry around Cu(II) and tetrahedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates were conducted against various fungi.http://dx.doi.org/10.1155/2010/701409
collection DOAJ
language English
format Article
sources DOAJ
author R. T. Vashi
C. D. Shelat
Himanshu Patel
spellingShingle R. T. Vashi
C. D. Shelat
Himanshu Patel
Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates
E-Journal of Chemistry
author_facet R. T. Vashi
C. D. Shelat
Himanshu Patel
author_sort R. T. Vashi
title Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates
title_short Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates
title_full Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates
title_fullStr Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates
title_full_unstemmed Synthesis, Spectroscopic Studies and Antifungal Activity of 2-[(4(3-Chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(H)-quinazolin-4-one Ligand and its Chelates
title_sort synthesis, spectroscopic studies and antifungal activity of 2-[(4(3-chlorophenyl) piperazine-1-yl)methyl]-3-[8-hydroxy quinolin-5-yl]-3(h)-quinazolin-4-one ligand and its chelates
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2010-01-01
description The novel ligand HL6 was synthesized using anthranilic acid and it was undergo the chelating reaction with Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) to prepare transition metal chelates. These chelates were characterized by physicochemical methods such as elemental analysis, conductometric studies, magnetic susceptibility, FT-IR, NMR and electronic spectra. The stoichiometry of the complexes has been found to be 1: 2 (Metal: ligand). An octahedral geometry around Co(II), Ni(II) and Mn(II), distorted octahedral geometry around Cu(II) and tetrahedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates were conducted against various fungi.
url http://dx.doi.org/10.1155/2010/701409
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AT cdshelat synthesisspectroscopicstudiesandantifungalactivityof243chlorophenylpiperazine1ylmethyl38hydroxyquinolin5yl3hquinazolin4oneligandanditschelates
AT himanshupatel synthesisspectroscopicstudiesandantifungalactivityof243chlorophenylpiperazine1ylmethyl38hydroxyquinolin5yl3hquinazolin4oneligandanditschelates
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