Role of MicroRNA-143 in Nerve Injury-Induced Upregulation of Dnmt3a Expression in Primary Sensory Neurons

Role of MicroRNA-143 in Nerve Injury-Induced Upregulation of Dnmt3a Expression in Primary Sensory Neurons

Peripheral nerve injury increased the expression of the DNA methyltransferase 3A (Dnmt3a) mRNA and its encoding Dnmt3a protein in injured dorsal root ganglia (DRG). This increase is considered as an endogenous instigator in neuropathic pain genesis through epigenetic silencing of pain-associated gen...

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Bibliographic Details
Main Authors: Bo Xu, Jing Cao, Jun Zhang, Shushan Jia, Shaogen Wu, Kai Mo, Guihua Wei, Lingli Liang, Xuerong Miao, Alex Bekker, Yuan-Xiang Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
miR-143
Dnmt3a
Oprm1
dorsal root ganglion
neuropathic pain
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00350/full

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