X-Ray Induced DNA Damage and Repair in Germ Cells of PARP1−/− Male Mice

X-Ray Induced DNA Damage and Repair in Germ Cells of PARP1−/− Male Mice

Poly(ADP-ribose)polymerase-1 (PARP1) is a nuclear protein implicated in DNA repair, recombination, replication, and chromatin remodeling. The aim of this study was to evaluate possible differences between PARP1−/− and wild-type mice regarding induction and repair of DNA lesions in irradiated male ge...

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Bibliographic Details
Main Authors: Eugenia Cordelli, Francesca Pacchierotti, Lorena Paris, Roberto Ranaldi, Patrizia Eleuteri, Anna Maria Fresegna, Paola Villani
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:International Journal of Molecular Sciences
Subjects:
poly(ADP-ribose)polymerase-1
DNA repair
male mouse germ cells
comet assay
H2AX phosphorylation
ionizing radiation
Online Access:http://www.mdpi.com/1422-0067/14/9/18078

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