The Influenza A Virus H3N2 Triggers the Hypersusceptibility of Airway Inflammatory Response via Activating the lncRNA TUG1/miR-145-5p/NF-κB Pathway in COPD

The Influenza A Virus H3N2 Triggers the Hypersusceptibility of Airway Inflammatory Response via Activating the lncRNA TUG1/miR-145-5p/NF-κB Pathway in COPD

Background: Patients with chronic obstructive pulmonary disease (COPD) are more susceptible to influenza A virus (IAV) with more severe symptoms, yet the underlying molecular mechanisms of the hypersusceptibility of airway inflammatory response remain unclear.Methods: The primary human bronchial epi...

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Bibliographic Details
Main Authors: You-Hui Tu, Yan Guo, Shuang Ji, Ji-Long Shen, Guang-He Fei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
COPD
influenza A virus
airway inflammatory hypersusceptibility
lncRNA TUG1
miR-145-5p
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.604590/full

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