Research advances in experiments on correlation between schizophrenia and myelin sheath abnormality
Schizophrenia, as a common mental disease, seriously threatens the physical and mental health of human beings. It is characterized by many mental and behavioral disorders, such as uncoordinated thinking and emotional mode which separated from the actual living environment. Patients with schizophr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2021-05-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/202109/14.pdf |
| Summary: | Schizophrenia, as a common mental disease, seriously threatens the physical and mental
health of human beings. It is characterized by many mental and behavioral disorders, such
as uncoordinated thinking and emotional mode which separated from the actual living
environment. Patients with schizophrenia are prone to relapse and deterioration due to
their long course of disease, resulting in the loss of labor force. It has been proved that the
occurrence and development of schizophrenia is closely related to the abnormal development
of oligodendrocytes, which have the function of myelin formation and the dysfunction of
myelin sheath itself. For a comprehensive understanding of myelin abnormal effects on
the pathogenesis of schizophrenia, this paper is to review the literature, then summarize
and discuss the animal experimental literature related to the abnormal myelin sheath in
schizophrenia from the perspectives of behavioristics, neuroimaging, protein expression and
stereology, in order to further clarify the influence of the abnormal myelin sheath on the
pathogenesis of schizophrenia and provide ideas for the diagnosis of schizophrenia and the
research and development of new drugs. |
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| ISSN: | 1007-1237 1007-1237 |