Functional coupling of chloride–proton exchanger ClC-5 to gastric H+,K+-ATPase

Functional coupling of chloride–proton exchanger ClC-5 to gastric H+,K+-ATPase

Summary It has been reported that chloride–proton exchanger ClC-5 and vacuolar-type H+-ATPase are essential for endosomal acidification in the renal proximal cells. Here, we found that ClC-5 is expressed in the gastric parietal cells which secrete actively hydrochloric acid at the luminal region of...

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Main Authors: Yuji Takahashi, Takuto Fujii, Kyosuke Fujita, Takahiro Shimizu, Taiga Higuchi, Yoshiaki Tabuchi, Hisato Sakamoto, Ichiro Naito, Koji Manabe, Shinichi Uchida, Sei Sasaki, Akira Ikari, Kazuhiro Tsukada, Hideki Sakai
Format: Article
Language:English
Published: The Company of Biologists 2013-11-01
Series:Biology Open
Subjects:
ClC-5
H+,K+-ATPase
Gastric acid
Tubulovesicle
Parietal cell
Online Access:http://bio.biologists.org/content/3/1/12

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