The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling

The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling

INO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps)  in INO80, showing that Arp8 and Arp4 module sense the DNA length separating...

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Main Authors: Sandipan Brahma, Mzwanele Ngubo, Somnath Paul, Maheshi Udugama, Blaine Bartholomew
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05710-7
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spelling doaj-e00fc131e6374772ad0cb36e70283b472021-05-11T09:42:38ZengNature Publishing GroupNature Communications2041-17232018-08-019111010.1038/s41467-018-05710-7The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodelingSandipan Brahma0Mzwanele Ngubo1Somnath Paul2Maheshi Udugama3Blaine Bartholomew4Department of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer CenterDepartment of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer CenterDepartment of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer CenterDepartment of Biochemistry and Molecular Biology, Southern Illinois UniversityDepartment of Epigenetics & Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer CenterINO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps)  in INO80, showing that Arp8 and Arp4 module sense the DNA length separating nucleosomes and regulate nucleosome remodeling.https://doi.org/10.1038/s41467-018-05710-7
collection DOAJ
language English
format Article
sources DOAJ
author Sandipan Brahma
Mzwanele Ngubo
Somnath Paul
Maheshi Udugama
Blaine Bartholomew
spellingShingle Sandipan Brahma
Mzwanele Ngubo
Somnath Paul
Maheshi Udugama
Blaine Bartholomew
The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling
Nature Communications
author_facet Sandipan Brahma
Mzwanele Ngubo
Somnath Paul
Maheshi Udugama
Blaine Bartholomew
author_sort Sandipan Brahma
title The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling
title_short The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling
title_full The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling
title_fullStr The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling
title_full_unstemmed The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling
title_sort arp8 and arp4 module acts as a dna sensor controlling ino80 chromatin remodeling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description INO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps)  in INO80, showing that Arp8 and Arp4 module sense the DNA length separating nucleosomes and regulate nucleosome remodeling.
url https://doi.org/10.1038/s41467-018-05710-7
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