Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795 and ACSL1 rs6552828

Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795 and ACSL1 rs6552828

There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years) deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (T...

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Bibliographic Details
Main Authors: Noriyuki eFuku, Zi-hong eHe, Fabian Sanchis Gomar, Helios ePareja Galeano, Ye eTIAN, Yasumichi eArai, Yukiko eAbe, Haruka eMurakami, Motohiko eMiyachi, Hirofumi eZempo, Hisashi eNaito, Thomas eYvert, Zoraida eVerde, Leticia eVenturini, Carmen eFiuza-Luces, Alejandro eSantos-Lozano, Gabriel eRodríguez, Giovanni eRicevuti, Nobuyoshi eHirose, Enzo eEmanuele, Nuria eGaratachea, Alejandro eLucia
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
polymorphisms
luciferase reporter
centenarians
gene association study
muscle and sarcopenia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00059/full

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http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00059/full

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