The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which includes ligand-dependent activation of ectopical...

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Bibliographic Details
Main Authors: Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:EBioMedicine
Subjects:
Acute myeloid leukemia
Tim-3
Galectin-9
NK cells
Anti-leukemia immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417302918

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http://www.sciencedirect.com/science/article/pii/S2352396417302918

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