Integrated Multi-Class Classification and Prediction of GPCR Allosteric Modulators by Machine Learning Intelligence

Integrated Multi-Class Classification and Prediction of GPCR Allosteric Modulators by Machine Learning Intelligence

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cell surface receptors that respond to various extracellular signals. The allosteric modulation of GPCRs has emerged in recent years as a promising approach for developing target-selective therapies. Moreover, the discover...

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Bibliographic Details
Main Authors: Tianling Hou, Yuemin Bian, Terence McGuire, Xiang-Qun Xie
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
GPCRs
allosteric regulation
machine learning
finger-prints
drug design
Online Access:https://www.mdpi.com/2218-273X/11/6/870

Internet

https://www.mdpi.com/2218-273X/11/6/870

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