Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury

Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury

Abstract Background In acute respiratory distress syndrome (ARDS), uncontrolled production of activators of coagulation and proinflammatory mediators results in a shift from an adequate local innate immune response to hypercoagulability and inflammation. This study aimed to investigate whether the p...

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Bibliographic Details
Main Authors: Jenny Juschten, Sarah Anne Ingelse, Martinus Adrianus Wilhelmus Maas, Armand Roelof Johan Girbes, Nicole Petra Juffermans, Marcus Josephus Schultz, Pieter Roel Tuinman
Format: Article
Language:English
Published: SpringerOpen 2019-07-01
Series:Intensive Care Medicine Experimental
Subjects:
Antithrombin
Alpha-1 protease inhibitor
Acute lung injury
ARDS
Lung injury model
Inflammation
Online Access:http://link.springer.com/article/10.1186/s40635-019-0240-7

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