Tissue macrophages: heterogeneity and functions

Tissue macrophages: heterogeneity and functions

Abstract Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance o...

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Main Authors: Siamon Gordon, Annette Plüddemann
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Biology
Online Access:http://link.springer.com/article/10.1186/s12915-017-0392-4
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spelling doaj-dfd98f7aac11499287b26e8ec45337172020-11-25T02:47:15ZengBMCBMC Biology1741-70072017-06-0115111810.1186/s12915-017-0392-4Tissue macrophages: heterogeneity and functionsSiamon Gordon0Annette Plüddemann1Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung UniversityNuffield Department of Primary Care Health Sciences, University of OxfordAbstract Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions.http://link.springer.com/article/10.1186/s12915-017-0392-4
collection DOAJ
language English
format Article
sources DOAJ
author Siamon Gordon
Annette Plüddemann
spellingShingle Siamon Gordon
Annette Plüddemann
Tissue macrophages: heterogeneity and functions
BMC Biology
author_facet Siamon Gordon
Annette Plüddemann
author_sort Siamon Gordon
title Tissue macrophages: heterogeneity and functions
title_short Tissue macrophages: heterogeneity and functions
title_full Tissue macrophages: heterogeneity and functions
title_fullStr Tissue macrophages: heterogeneity and functions
title_full_unstemmed Tissue macrophages: heterogeneity and functions
title_sort tissue macrophages: heterogeneity and functions
publisher BMC
series BMC Biology
issn 1741-7007
publishDate 2017-06-01
description Abstract Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions.
url http://link.springer.com/article/10.1186/s12915-017-0392-4
work_keys_str_mv AT siamongordon tissuemacrophagesheterogeneityandfunctions
AT annettepluddemann tissuemacrophagesheterogeneityandfunctions
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