Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with overlapping pathomechanisms, neurobehavioral features, and genetic etiologies. Individuals diagnosed with either disorder exhibit symptoms within a clinical spectrum. Symptoms of ALS involve ne...

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Bibliographic Details
Main Authors: Kyle J. Trageser, Chad Smith, Francis J. Herman, Kenjiro Ono, Giulio Maria Pasinetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
frontotemporal dementia (FTD)
C9orf72
innate immunity
TDP-43
reactive oxygen species (ROS)
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01298/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.01298/full

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