Advances in Mycobacterium siderophore-based drug discovery

• Main Authors: Jun-li He, Jian-ping Xie
• Format: Article
• Language: English
• Published: Elsevier 2011-06-01
• Series: Acta Pharmaceutica Sinica B
• Subjects: Tuberculosis; Mycobacterium tuberculosis; Siderophore; Drug vector; Drug design
• Online Access: http://www.sciencedirect.com/science/article/pii/S2211383511000098

Tuberculosis remains a public health threat of global proportions. Iron is a scarce resource indispensable to both host and pathogen during infection with Mycobacterium tuberculosis, the causative agent of tuberculosis. Siderophores are critical molecules for iron acquisition under iron-limiting conditions and, as a very efficient pathogen, M. tuberculosis has evolved elaborate siderophores knowledge of which is being intensively translated into clinical practice. This paper summarizes the structures, types and physiological functions of Mycobacterium siderophores with emphasis on siderophore-inspired design of drugs and drug delivery vehicles.