Synthesis, enzyme inhibitory kinetics mechanism and computational study of N-(4-methoxyphenethyl)-N-(substituted)-4-methylbenzenesulfonamides as novel therapeutic agents for Alzheimer’s disease

Synthesis, enzyme inhibitory kinetics mechanism and computational study of N-(4-methoxyphenethyl)-N-(substituted)-4-methylbenzenesulfonamides as novel therapeutic agents for Alzheimer’s disease

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The present study comprises the synthesis of a new series of sulfonamides derived from 4-methoxyphenethylamine (1). The synthesis was initiated by the reaction of 1 with 4-methylbenzenesulfonyl chloride (2) in aqueous sodium carbonate solution at pH 9 to yield N-(4-methoxyphenethyl)-4-methylbenzensu...

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Bibliographic Details
Main Authors: Muhammad Athar Abbasi, Mubashir Hassan, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, Syed Adnan Ali Shah, Hussain Raza, Sung Yum Seo
Format: Article
Language:English
Published: PeerJ Inc. 2018-06-01
Series:PeerJ
Subjects:
Sulfonamides
Molecular docking
Acetylcholinesterase
Alkyl/aralkyl halides
Spectral analysis
Online Access:https://peerj.com/articles/4962.pdf
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