A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

Abstract Background Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, caused by quantitative and qualitative changes in von Willebrand factor (VWF). The biology of VWD, studied in canine, porcine, and murine models, differ in species‐specific biology of VWF and the amenabi...

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Bibliographic Details
Main Authors: Jessica Garcia, Veronica H. Flood, Sandra L. Haberichter, Scot A. Fahs, Jeremy G. Mattson, Aron M. Geurts, Mark Zogg, Hartmut Weiler, Qizhen Shi, Robert R. Montgomery
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
CRISPR
factor VIII
rat model
severe von Willebrand disease
von Willebrand factor
Online Access:https://doi.org/10.1002/rth2.12280

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