Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

The antipsychotic drug olanzapine is associated with serious obesity side effects. Hypothalamic astrocytes and associated toll-like receptor-4 (TLR4) signaling play an essential role in obesity pathogenesis. This study investigated the effect of olanzapine on astrocytes and TLR4 signaling both in vi...

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Bibliographic Details
Main Authors: Meng He, Kun Qian, Ying Zhang, Xu-Feng Huang, Chao Deng, Baohua Zhang, Guanbin Gao, Jing Li, Hao Xie, Taolei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Neuroscience
Subjects:
antipsychotics
weight gain
glial fibrillary acidic protein
S100 calcium binding protein B
TLR4-MyD88 signaling
endoplasmic reticulum stress
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.589650/full

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