Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits

Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits

Doxorubicin (Dox) is a chemotherapeutic agent used widely to treat a variety of malignant cancers. However, Dox chemotherapy is associated with several adverse effects, including “chemobrain,” the observation that cancer patients exhibit through learning and memory difficulties extending even beyond...

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Bibliographic Details
Main Authors: Ahmad H. Alhowail, Priyanka D. Pinky, Matthew Eggert, Jenna Bloemer, Lauren N. Woodie, Manal A. Buabeid, Subhrajit Bhattacharya, Shanese L. Jasper, Dwipayan Bhattacharya, Muralikrishnan Dhanasekaran, Martha Escobar, Robert D. Arnold, Vishnu Suppiramaniam
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Doxorubicin
Chemobrain
Long-term potentiation
AMPA
Cognitive deficits
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021015590

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