Glycine reduces liver lipid peroxidation in neonatal hypoxia/reoxygenation-induced necrotizing enterocolitis

• Main Authors: Karine Furtado Meyer, José Luiz Martins, Mauricio Macedo, Luiz Gonzaga de Freitas Filho, Maria Luiza Vilela Oliva, Francy Reis da Silva Patrício, Lina Wang, Ana Cristina Garcia Ferreira
• Format: Article
• Language: English
• Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2006-06-01
• Series: Einstein (São Paulo)
• Subjects: Glycine; Enterocolitis; necrotizing; Ischemia; Liver/injuries
• Online Access: http://www.einstein.br/revista/arquivos/PDF/273-Einstein%20vol4%20n2_108.pdf

Objective: To assess the protective effect of glycine in liver ofneonatal hypoxia/reoxygenation-induced necrotizing enterocolitisin rats. Methods: Forty-four (44) neonatal Wistar rats weredistributed into three groups: G1 – normal control group (n=12);G2 Group (n=16) with animals that underwent hypoxiareoxygenation;G3 Group (n=17) with animals submitted tohypoxia-reoxygenation following a 5% intraperitoneal glycineinfusion. The groups were subdivided into A: euthanasia 12 h afterhypoxia-reoxygenation and B: euthanasia 72 h after hypoxiareoxygenation.The liver was removed for determination of tissuemalondialdehyde. Results: Malondialdehyde values did not differsignificantly in subgroups G1 and G3. The animals in G2A hadmean malondialdehyde values significantly lower than those inG2B. Malondialdehyde values did not differ significantly for animalsin subgroup A. In subgroup B, the malondialdehyde values did notdiffer significantly among the animals in G1 and G3. G2 animalshad mean malondialdehyde values significantly higher than G3animals. Conclusion: Glycine reduces liver lipid peroxidation inhypoxia/reoxygenation-induced necrotizing enterocolitis.