Heterogeneity of Integrin α<sub>IIb</sub>β<sub>3</sub> Function in Pediatric Immune Thrombocytopenia Revealed by Continuous Flow Cytometry Analysis

Heterogeneity of Integrin α<sub>IIb</sub>β<sub>3</sub> Function in Pediatric Immune Thrombocytopenia Revealed by Continuous Flow Cytometry Analysis

Immune thrombocytopenia (ITP) is an autoimmune condition primarily induced by the loss of immune tolerance to the platelet glycoproteins. Here we develop a novel flow cytometry approach to analyze integrin α<sub>IIb</sub>β<sub>3</sub> functioning in ITP in comparison with Gla...

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Bibliographic Details
Main Authors: Alexey A. Martyanov, Daria S. Morozova, Maria A. Sorokina, Aleksandra A. Filkova, Daria V. Fedorova, Selima S. Uzueva, Elena V. Suntsova, Galina A. Novichkova, Pavel A. Zharkov, Mikhail A. Panteleev, and Anastasia N. Sveshnikova
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
platelet
integrin αIIbβ3
calcium signaling
immune thrombocytopenia
blood platelet disorders
flow cytometry
Online Access:https://www.mdpi.com/1422-0067/21/9/3035

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