Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Astrocytes are key players in the progression of amyotrophic lateral sclerosis (ALS). Previously, gene expression profiling of astrocytes from the pre-symptomatic stage of the SOD1G93A model of ALS has revealed reduced lactate metabolism and altered trophic support. Here, we have performed microarra...

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Bibliographic Details
Main Authors: David John Baker, Daniel J Blackburn, Marcus eKeatinge, Dilraj eSokhi, Paulius eViskaitis, Paul Roy Heath, Laura eFerraiuolo, Janine eKirby, Pamela Jean Shaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Microarray
motor neuron
neurodegeneration
Superoxide dismutase 1
Cholesterol/steroid
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00410/full

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