Expression and Significance of Cadherins and Its Subtypes in Development and Progression of Oral Cancers: A Review
Cadherins are a family of transmembranous glycoproteins responsible for calcium-dependent intercellular adhesion. Absence or loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for extracellular matrices. That is wh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5907/11964_CE(RA1)_F(T)_PF1(AGAK)_PFA(P)_PF2(PAG).pdf |
| Summary: | Cadherins are a family of transmembranous glycoproteins responsible for calcium-dependent intercellular adhesion. Absence or loss
of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for
extracellular matrices. That is why cadherin expression is considered to be a decisive indicator for differentiation, aggressive behaviour,
high proliferation, metastasis, poor prognosis and invasiveness of human carcinoma cells. In this review, the role of cadherin expression
was focused on, both in development and carcinogenesis, paying particular attention to mechanisms involved in its down-regulation.
The elements common to this process in both physiological and pathological situations was analysed, particularly in relation to one of
the most common malignancy, oral squamous cell carcinoma. |
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| ISSN: | 2249-782X 0973-709X |