Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites

Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites

To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight re...

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Main Authors: Eri Sagawa, Hironao Okubo, Hitoshi Ando, Yushi Sorin, Ryo Kanazawa, Eisuke Nakadera, Hiroo Fukada, Shigehiro Kokubu, Akihisa Miyazaki
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319300295
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spelling doaj-df7951eb884045a784ff180e7de1f7272020-11-25T00:52:24ZengElsevierJournal of Pharmacological Sciences1347-86132019-04-011394373376Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascitesEri Sagawa0Hironao Okubo1Hitoshi Ando2Yushi Sorin3Ryo Kanazawa4Eisuke Nakadera5Hiroo Fukada6Shigehiro Kokubu7Akihisa Miyazaki8Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, JapanDepartment of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan; Corresponding author. Department of Gastroenterology, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima-ku, Tokyo, 177-8521, Japan. Fax: +81 3 5923 3217.Department of Cellular and Molecular Function Analysis, Kanazawa University Graduate School of Medical Sciences, Ishikawa, JapanDepartment of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, JapanDepartment of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, JapanDepartment of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, JapanDepartment of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, JapanDepartment of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan; Department of Gastroenterology, Shinyurigaoka General Hospital, Kanagawa, JapanDepartment of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, JapanTo investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight reduction of >1.5 kg/week. Serum albumin levels were significantly lower in responders than in non-responders (P = 0.031). However, the pharmacokinetics varied greatly among individuals and was not relevant to the clinical response. Keywords: Tolvaptan, Pharmacokinetics, Hepatic edemahttp://www.sciencedirect.com/science/article/pii/S1347861319300295
collection DOAJ
language English
format Article
sources DOAJ
author Eri Sagawa
Hironao Okubo
Hitoshi Ando
Yushi Sorin
Ryo Kanazawa
Eisuke Nakadera
Hiroo Fukada
Shigehiro Kokubu
Akihisa Miyazaki
spellingShingle Eri Sagawa
Hironao Okubo
Hitoshi Ando
Yushi Sorin
Ryo Kanazawa
Eisuke Nakadera
Hiroo Fukada
Shigehiro Kokubu
Akihisa Miyazaki
Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
Journal of Pharmacological Sciences
author_facet Eri Sagawa
Hironao Okubo
Hitoshi Ando
Yushi Sorin
Ryo Kanazawa
Eisuke Nakadera
Hiroo Fukada
Shigehiro Kokubu
Akihisa Miyazaki
author_sort Eri Sagawa
title Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
title_short Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
title_full Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
title_fullStr Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
title_full_unstemmed Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
title_sort plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2019-04-01
description To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight reduction of >1.5 kg/week. Serum albumin levels were significantly lower in responders than in non-responders (P = 0.031). However, the pharmacokinetics varied greatly among individuals and was not relevant to the clinical response. Keywords: Tolvaptan, Pharmacokinetics, Hepatic edema
url http://www.sciencedirect.com/science/article/pii/S1347861319300295
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