A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes[S]
Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3′-untranslated region (3′-UTR). However, the underlying mechanism of translational regulation of CYP7A...
Main Authors: | Kwang-Hoon Song, Tiangang Li, Erika Owsley, John Y.L. Chiang |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2010-08-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520370589 |
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