Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine1[S]

Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine1[S]

Immunization with homologous malondialdehyde (MDA)-modified LDL (MDA-LDL) leads to atheroprotection in experimental models supporting the concept that a vaccine to oxidation-specific epitopes (OSEs) of oxidized LDL could limit atherogenesis. However, modification of human LDL with OSE to use as an i...

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Bibliographic Details
Main Authors: Ayelet Gonen, Lotte F. Hansen, William W. Turner, Erica N. Montano, Xuchu Que, Apaїs Rafia, Meng-Yun Chou, Philipp Wiesner, Dimitrios Tsiantoulas, Maripat Corr, Michael S. VanNieuwenhze, Sotirios Tsimikas, Christoph J. Binder, Joseph L. Witztum, Karsten Hartvigsen
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Journal of Lipid Research
Subjects:
oxidation-specific epitopes
malondialdehyde-acetaldehyde adducts
adaptive immunity
humoral immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350173

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