Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism

Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism

Patients infected with the Dengue virus (DENV) often present with a massive generation of DENV-specific antibody-secreting cells (ASCs) in the blood. In some cases, these ASCs represent more than 50% of the circulating B cells, a higher magnitude than those induced by other infections, vaccinations,...

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Bibliographic Details
Main Authors: Vivian Bonezi, Allan H. D. Cataneo, Maryana S. F. Branquinho, Maysa B. B. Silva, Patricia Gonzalez-Dias, Samuel S. Pereira, Luís C. de Souza Ferreira, Helder I. Nakaya, Ana Campa, Pryscilla F. Wowk, Eduardo L. V. Silveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
Dengue virus
B cell differentiation
antibody-secreting cells
tryptophan metabolism
flaviviruses
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00020/full

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