Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to p...
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Bibliographic Details
| Main Authors: |
Shigeru Hashimoto,
Shuji Mikami,
Hirokazu Sugino,
Ayumu Yoshikawa,
Ari Hashimoto,
Yasuhito Onodera,
Shotaro Furukawa,
Haruka Handa,
Tsukasa Oikawa,
Yasunori Okada,
Mototsugu Oya,
Hisataka Sabe |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10656
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