Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation

Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation

While the toxicity of metals and metalloids, like arsenic, cadmium, mercury, lead and chromium, is undisputed, the underlying molecular mechanisms are not entirely clear. General consensus holds that proteins are the prime targets; heavy metals interfere with the physiological activity of specific,...

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Bibliographic Details
Main Authors: Markus J. Tamás, Sandeep K. Sharma, Sebastian Ibstedt, Therese Jacobson, Philipp Christen
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Biomolecules
Subjects:
protein folding
protein aggregation
chaperone
protein degradation
protein
metal toxicity
metalloid toxicity
yeast
Online Access:http://www.mdpi.com/2218-273X/4/1/252

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