Insights into the Origin of Distinct Medin Fibril Morphologies Induced by Incubation Conditions and Seeding

Insights into the Origin of Distinct Medin Fibril Morphologies Induced by Incubation Conditions and Seeding

Incubation conditions are an important factor to consider when studying protein aggregation in vitro. Here, we employed biophysical methods and atomic force microscopy to show that agitation dramatically alters the morphology of medin, an amyloid protein deposited in the aorta. Agitation reduces the...

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Bibliographic Details
Main Authors: Hannah A. Davies, Chiu Fan Lee, Leanne Miller, Lu-Ning Liu, Jillian Madine
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
atomic force microscopy
amyloid
aortic medial amyloid/medin
mathematical modelling
aggregation
Online Access:http://www.mdpi.com/1422-0067/19/5/1357

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