The quaternary assembly of KRas4B with Raf-1 at the membrane

The quaternary assembly of KRas4B with Raf-1 at the membrane

Proximally located in the membrane, oncogenic Ras dimers (or nanoclusters) can recruit and promote Raf dimerization and MAPK (Raf/MEK/ERK) signaling. Among Ras isoforms, KRas4B is the most frequently mutated. Recent data on the binary KRas4B–Raf-1 complex suggested that Raf-1 CRD not only executes m...

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Bibliographic Details
Main Authors: Hyunbum Jang, Mingzhen Zhang, Ruth Nussinov
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Ras dimerization
Nanoclusters
KRAS
C-Raf
RBD
CRD
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020300301

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